A revolver might be what you need unless you can find a semi with an ambidextrous safety that you like. A 1911 is pretty big unless you go compact model although there are some folks that do conceal carry them. I've found that smaller is more comfortable. I can carry a Glock 30 (.45) but prefer the Taurus PT740 (.40) due to it's thinner size. Neither of these guns has an ambidextrous safety but the Glock doesn't even have a separate manual safety. Just the trigger safety.
I like carrying appendix style so I'm just more comfortable having the extra manual safety on the Taurus. IMO, whatever you do, carry in a holster that covers the finger guard/trigger area. You don't want something finding it's way in there and accidentally discharging the gun while it's tucked in your pants. Could be life altering. Specially if you carry appendix style.